A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets.
Identifieur interne : 001283 ( Main/Exploration ); précédent : 001282; suivant : 001284A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets.
Auteurs : Tomy Joseph [États-Unis] ; Josephine Mcauliffe ; Bin Lu ; Leatrice Vogel ; David Swayne ; Hong Jin ; George Kemble ; Kanta SubbaraoSource :
- Virology [ 0042-6822 ] ; 2008.
Descripteurs français
- KwdFr :
- Adaptation physiologique, Animaux, Anticorps antiviraux (sang), Basse température, Embryon de poulet, Furets (immunologie), Furets (virologie), Grippe chez les oiseaux (), Grippe chez les oiseaux (immunologie), Grippe chez les oiseaux (virologie), Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (mortalité), Infections à Orthomyxoviridae (virologie), Phénotype, Poulets (virologie), Réplication virale, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (pathogénicité), Vaccins antigrippaux (administration et posologie), Vaccins antigrippaux (immunologie), Vaccins atténués (administration et posologie), Vaccins atténués (immunologie), Virus de la grippe A (), Virus de la grippe A (génétique), Virus de la grippe A (immunologie), Virus de la grippe A (pathogénicité), Virus recombinants (génétique), Virus recombinants (immunologie), Virus recombinants (pathogénicité).
- MESH :
- administration et posologie : Vaccins antigrippaux, Vaccins atténués.
- génétique : Sous-type H2N2 du virus de la grippe A, Virus de la grippe A, Virus recombinants.
- immunologie : Furets, Grippe chez les oiseaux, Infections à Orthomyxoviridae, Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux, Vaccins atténués, Virus de la grippe A, Virus recombinants.
- mortalité : Infections à Orthomyxoviridae.
- pathogénicité : Sous-type H2N2 du virus de la grippe A, Virus de la grippe A, Virus recombinants.
- sang : Anticorps antiviraux.
- virologie : Furets, Grippe chez les oiseaux, Infections à Orthomyxoviridae, Poulets.
- Adaptation physiologique, Animaux, Basse température, Embryon de poulet, Grippe chez les oiseaux, Infections à Orthomyxoviridae, Phénotype, Réplication virale, Souris, Souris de lignée BALB C, Virus de la grippe A.
English descriptors
- KwdEn :
- Adaptation, Physiological, Animals, Antibodies, Viral (blood), Chick Embryo, Chickens (virology), Cold Temperature, Ferrets (immunology), Ferrets (virology), Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H2N2 Subtype (pathogenicity), Influenza A virus (classification), Influenza A virus (genetics), Influenza A virus (immunology), Influenza A virus (pathogenicity), Influenza Vaccines (administration & dosage), Influenza Vaccines (immunology), Influenza in Birds (immunology), Influenza in Birds (prevention & control), Influenza in Birds (virology), Mice, Mice, Inbred BALB C, Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (mortality), Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Phenotype, Reassortant Viruses (genetics), Reassortant Viruses (immunology), Reassortant Viruses (pathogenicity), Vaccines, Attenuated (administration & dosage), Vaccines, Attenuated (immunology), Virus Replication.
- MESH :
- chemical , administration & dosage : Influenza Vaccines, Vaccines, Attenuated.
- chemical , blood : Antibodies, Viral.
- classification : Influenza A virus.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza A virus, Reassortant Viruses.
- immunology : Ferrets, Influenza A Virus, H2N2 Subtype, Influenza A virus, Influenza Vaccines, Influenza in Birds, Orthomyxoviridae Infections, Reassortant Viruses, Vaccines, Attenuated.
- mortality : Orthomyxoviridae Infections.
- pathogenicity : Influenza A Virus, H2N2 Subtype, Influenza A virus, Reassortant Viruses.
- prevention & control : Influenza in Birds, Orthomyxoviridae Infections.
- virology : Chickens, Ferrets, Influenza in Birds, Orthomyxoviridae Infections.
- Adaptation, Physiological, Animals, Chick Embryo, Cold Temperature, Mice, Mice, Inbred BALB C, Phenotype, Virus Replication.
Abstract
The appearance of human infections caused by avian influenza A H7 subtype viruses underscores their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. A live attenuated H7N3 virus vaccine was generated by reverse genetics using the HA and NA genes of a low pathogenicity A/chicken/BC/CN-6/04 (H7N3) virus and the six internal protein genes of the cold-adapted A/Ann Arbor/6/60 ca (H2N2) virus. The reassortant H7N3 BC 04 ca vaccine virus was temperature sensitive and showed attenuation in mice and ferrets. Intranasal immunization with one dose of the vaccine protected mice and ferrets when challenged with homologous and heterologous H7 viruses. The reassortant H7N3 BC 04 ca vaccine virus showed comparable levels of attenuation, immunogenicity and efficacy in mice and ferret models. The safety, immunogenicity, and efficacy of this vaccine in mice and ferrets support the evaluation of this vaccine in clinical trials.
DOI: 10.1016/j.virol.2008.05.021
PubMed: 18585748
Affiliations:
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sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name></author><author><name sortKey="Swayne, David" sort="Swayne, David" uniqKey="Swayne D" first="David" last="Swayne">David Swayne</name></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name></author><author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="RBID">pubmed:18585748</idno><idno type="pmid">18585748</idno><idno type="doi">10.1016/j.virol.2008.05.021</idno><idno type="wicri:Area/PubMed/Corpus">000256</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" 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A</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The appearance of human infections caused by avian influenza A H7 subtype viruses underscores their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. A live attenuated H7N3 virus vaccine was generated by reverse genetics using the HA and NA genes of a low pathogenicity A/chicken/BC/CN-6/04 (H7N3) virus and the six internal protein genes of the cold-adapted A/Ann Arbor/6/60 ca (H2N2) virus. The reassortant H7N3 BC 04 ca vaccine virus was temperature sensitive and showed attenuation in mice and ferrets. Intranasal immunization with one dose of the vaccine protected mice and ferrets when challenged with homologous and heterologous H7 viruses. The reassortant H7N3 BC 04 ca vaccine virus showed comparable levels of attenuation, immunogenicity and efficacy in mice and ferret models. The safety, immunogenicity, and efficacy of this vaccine in mice and ferrets support the evaluation of this vaccine in clinical trials.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><noCountry><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name><name sortKey="Lu, Bin" sort="Lu, Bin" uniqKey="Lu B" first="Bin" last="Lu">Bin Lu</name><name sortKey="Mcauliffe, Josephine" sort="Mcauliffe, Josephine" uniqKey="Mcauliffe J" first="Josephine" last="Mcauliffe">Josephine Mcauliffe</name><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><name sortKey="Swayne, David" sort="Swayne, David" uniqKey="Swayne D" first="David" last="Swayne">David Swayne</name><name sortKey="Vogel, Leatrice" sort="Vogel, Leatrice" uniqKey="Vogel L" first="Leatrice" last="Vogel">Leatrice Vogel</name></noCountry><country name="États-Unis"><noRegion><name sortKey="Joseph, Tomy" sort="Joseph, Tomy" uniqKey="Joseph T" first="Tomy" last="Joseph">Tomy Joseph</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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